Lucidenic acid A inhibits the binding of hACE2 receptor with spike protein to prevent SARS-CoV-2 invasion

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Scientists have identified lucidenic acid A, one of the bioactive compounds of Ganoderma lucidum

source:Flickr

as a potential inhibitor of intense acute respiratory syndrome covid-19 2 (SARS-CoV-2) host cellular access.

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Background Chinese traditional medicinal plants are rich sources of many bioactive compounds that exhibit anti-inflammatory, antiviral, antioxidative, and anticancer activities.

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Regarding antiviral potency, bioactive compounds isolated from about 30 medicinal plants have been found to inhibit coronavirus infection through various mechanisms.

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Fungal bioactive compounds, including polysaccharides, terpenes, and cordycepin

Fungal bioactive compounds, including polysaccharides, terpenes, and cordycepin

The initial screening of Ganoderma lucidum led to the identification of 54 bioactive compounds and 574 antiviral target proteins.

source:Flickr

Notably, lucidenic acid A prevents the host cell entry of wild-type SARS-CoV-2 and its variants, especially omicron.